- A rare goblet cell adenocarcinoma arising from Barrett’s esophagus: the first reported case in the esophagus
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Chi Eun Oh, Sung Eun Kim, Sun-Ju Oh
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J Pathol Transl Med. 2024;58(2):81-86. Published online January 8, 2024
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DOI: https://doi.org/10.4132/jptm.2023.12.26
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 Abstract
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- Goblet cell adenocarcinoma (GCA) is a rare and distinctive amphicrine tumor comprised of goblet-like mucinous cells and neuroendocrine cells. It is believed to originate from pluripotent stem cells located at the base of crypts. GCA predominantly arises from the appendix, with a few reported cases in extra-appendiceal locations such as the colorectum, small intestine, and stomach. In this case report, we present a unique instance of a 64-year-old male who initially received a diagnosis of neuroendocrine carcinoma in the distal esophagus based on biopsy but, following resection, was subsequently re-diagnosed with GCA arising from Barrett’s esophagus.
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